NK-92MI Cells Engineered with Anti-claudin-6 Chimeric Antigen Receptors in Immunotherapy for Ovarian Cancer
Junping Li, Hong Hu, Hui Lian, Shuo Yang, Manting Liu, Jinping He, Bihui Cao, Dongni Chen, Yuling Hu, Cheng Zhi, Yan Shen, Xiaodie Ye, Bingjia He, Ming Zhao, Weijun Fan, Linfeng Xu, Rom S. Leidner, Qingde Wu, Lili Yang, Zhenfeng Zhang
Abstract
: These results indicate that CLDN6-CAR NK cells possess strong antitumor activity and represent a promising immunotherapeutic modality for ovarian cancer.
Topics & Concepts
Chimeric antigen receptorCytotoxic T cellCancer researchOvarian cancerNKG2DBiologyAntigenWestern blotImmunotherapyMolecular biologyCancerIn vitroImmunologyImmune systemGeneGeneticsBiochemistryImmune Cell Function and InteractionCAR-T cell therapy researchReproductive System and Pregnancy