Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
Hui Xie, Felix K.‐H. Chun, Jochen Rutz, Roman A. Blaheta
Abstract
Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.
Topics & Concepts
SulforaphaneReactive oxygen speciesGlucosinolateCruciferous vegetablesCancer researchCancerChemistryOxidative damageBladder cancerOxidative stressSuppressorBiologyMedicineBiochemistryInternal medicineBotanyBrassicaGenomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsCircadian rhythm and melatonin