Ca2+ signaling and metabolic stress-induced pancreatic β-cell failure
Mark A. Magnuson, Anna B. Osipovich
Abstract
Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intracellular Ca 2+ concentration ([Ca 2+ ] i ), brought on by persistent metabolic stimulation of β-cells, causes β-cell dysfunction and failure by adversely affecting β-cell function, structure, and identity. This mini-review builds on several recent reviews that also describe how excess [Ca 2+ ] i impairs β-cell function.
Topics & Concepts
Signal transductionCell biologyMedicineBiologyChemistryInternal medicineBioinformaticsCancer researchEndocrinologyComputational biologyPancreatic function and diabetesEndoplasmic Reticulum Stress and DiseaseDiabetes and associated disorders