Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function
Jan Martínek, Jianan Lin, Kyung In Kim, Victor G. Wang, Te-Chia Wu, Michael Chiorazzi, Hannah Boruchov, Ananya Gulati, Shamreethaa Seeniraj, Lili Sun, Florentina Marches, Paul Robson, Anthony Rongvaux, Richard A. Flavell, Joshy George, Jeffrey H. Chuang, Jacques Banchereau, Karolina Palucka
Abstract
cell signature represents a candidate biomarker and suggests that reprogramming of stromal macrophages to acquire DC function may offer a therapeutic opportunity for metastatic cancers.
Topics & Concepts
CD14Stromal cellMelanomaBiologyCancer researchLaser capture microdissectionReprogrammingCD163Gene signatureImmune systemPhenotypeImmunologyCellGene expressionGeneBiochemistryGeneticsImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersImmune cells in cancer