Label-Free Micro Probe Optical Fiber Biosensor for Selective and Highly Sensitive Glucose Detection
Xuegang Li, Pengqi Gong, Yanan Zhang, Xue Zhou
Abstract
Blood glucose monitoring is very important for the prevention, control and treatment of diabetes. However, the application of existing glucose sensors is limited by poor bio-compatibility, complex readout approaches, slow response and complex fabrication. Most significantly, most sensors cannot meet the necessities of high-sensitivity and large-range simultaneously. Herein, we proposed a high-selective microprobe glucose optical fiber biosensor based on surface plasmon resonance (SPR), which might not solely bring high-sensitivity detection, however additionally cover the concentration range of human glucose. The experimental results demonstrate that the detection range reaches 0-200 mg/dL, and the maximum glucose concentration sensitivity reaches 0.1688 nm/(mg/dL). The limit of detection (LOD) was calculated to be 4 mg/dL. Furthermore, it is verified that the sensor resists the interference of sodium ions, potassium ions, sucrose, chitosan. The designed sensor with the advantage of high-selectivity, high-sensitivity and large-range has great potential for real-time, continuous glucose monitoring in the biological medicine fields.