Modeling SARS-CoV-2 spike/ACE2 protein–protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related human protein targets, for COVID-19 handling in the 3PM context
Vincenzo Tragni, Francesca Preziusi, Luna Laera, Angelo Onofrio, Ivan Mercurio, Simona Todisco, Mariateresa Volpicella, Anna Grassi, Ciro Leonardo Pierri
Topics & Concepts
Context (archaeology)Spike (software development)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyMutationComputational biologyGeneticsGeneCoronavirus disease 2019 (COVID-19)MedicineInfectious disease (medical specialty)DiseaseComputer sciencePaleontologyPathologySoftware engineeringSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesvaccines and immunoinformatics approaches