Photoredox-catalyzed direct C–H monofluoromethylation of heteroarenes
Nagarajan Ramkumar, Ketrina Plantus, Melita Ozola, Anatoly Mishnev, Vizma Nikolajeva, Māris Seņkovs, Maksim Ošeka, Janis Veliks
Abstract
We report a photo-redox catalyzed radical C–H monofluoromethylation of heterocycles, thus demonstrating this process and the importance of the monofluoromethyl unit in medicinal and drug discovery purposes.
Topics & Concepts
ChemistryCatalysisPhotoredox catalysisCombinatorial chemistryMedicinal chemistryPhotocatalysisOrganic chemistryFluorine in Organic Chemistry