A Solution to Antifolate Resistance in Group B <i>Streptococcus</i> : Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim
Schuyler A. Chambers, Rebecca E. Moore, Kelly M. Craft, Harrison C. Thomas, Rishub K. Das, Shannon D. Manning, Simona G. Codreanu, Stacy D. Sherrod, David M. Aronoff, John A. McLean, Jennifer A. Gaddy, Steven D. Townsend
Abstract
is an important human pathogen that causes serious infections during pregnancy which can lead to chorioamnionitis, funisitis, premature rupture of gestational membranes, preterm birth, neonatal sepsis, and death. GBS is evolving antimicrobial resistance mechanisms, and the work presented in this paper provides evidence that prebiotics such as human milk oligosaccharides can act as adjuvants to restore the utility of antibiotics.
Topics & Concepts
Neonatal sepsisStreptococcus agalactiaeAntibiotic resistanceChorioamnionitisAntibioticsGroup BMedicineStreptococcusMicrobiologyPregnancySepsisImmunologyBiologyGestational ageBacteriaInternal medicineGeneticsNeonatal and Maternal InfectionsInfant Nutrition and HealthNeonatal Health and Biochemistry