Stratified medicine for acute and chronic coronary syndromes: A patient-tailored approach
Rocco Antonio Montone, Thomas J. Ford, Mattía Galli, Riccardo Rinaldi, A. Bland, Andrew Morrow, Dominick J. Angiolillo, Colin Berry, Juan Carlos Kaski, Filippo Crea
Abstract
The traditional approach to management of cardiovascular disease relies on grouping clinical presentations with common signs and symptoms into pre-specified disease pathways, all uniformly treated according to evidence-based guidelines ("one-size-fits-all"). The goal of precision medicine is to provide the right treatment to the right patients at the right time, combining data from time honoured sources (e.g., history, physical examination, imaging, laboratory) and those provided by multi-omics technologies. In patients with ischemic heart disease, biomarkers and intravascular assessment can be used to identify endotypes with different pathophysiology who may benefit from distinct treatments. This review discusses strategies for the application of stratified management to patients with acute and chronic coronary syndromes.