Underweight Is Associated with Poor Prognosis in Heart Failure with Preserved Ejection Fraction
Yutaka Matsuhiro, Masami Nishino, Kohei Ukita, Akito Kawamura, Hitoshi Nakamura, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Akihiro Tanaka, Yasuharu Matsunaga‐Lee, Masamichi Yano, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi, Takahisa Yamada, Yoshio Yasumura, Shunsuke Tamaki, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Yohei Sotomi, Daisaku Nakatani, Shungo Hikoso, Yasushi Sakata, on behalf of Osaka CardioVascular Conference (OCVC) -Heart Failure Investigators
Abstract
), normal weight (18.5 ≤ BMI < 23), and overweight (23 ≤ BMI). The underweight group consisted of 187 patients (22%). Over a mean follow-up of 407 days, 105 deaths were reported as all-cause mortality. On multivariable Cox analysis, the underweight group was determined to be significantly associated with higher risk of all-cause mortality than the normal and overweight groups (Hazard ratios [HR]: 2.33; 95% confidence intervals [CI]: 1.45-3.75, P < 0.001; HR: 3.54; 95% CI: 1.99-6.29, P < 0.001, respectively), after adjustment for age, sex, vital signs, and comorbidities.Underweight is a useful predictor of poor prognosis in patients with HFpEF in Asian population.