MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
Maria Grazia Rodriquenz, Giandomenico Roviello, Alberto D’Angelo, Daniele Lavacchi, Franco Roviello, Karol Połom
Abstract
Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.
Topics & Concepts
MedicineImmunotherapyCancer immunotherapyInternal medicineCancerOncologyImmunologyViral-associated cancers and disordersImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers