Small extracellular vesicle-loaded bevacizumab reduces the frequency of intravitreal injection required for diabetic retinopathy
Shivakumar K Reddy, Abhijna R Ballal, S Shailaja, Raviraja N. Seetharam, Chandrashekar H Raghu, Runali Sankhe, Kanthilatha Pai, Tenzin Tender, Mary Mathew, Annayya R. Aroor, Ashok K. Shetty, Shalini Adiga, Vasudha Devi, Manjunatha S. Muttigi, Dinesh Upadhya
Abstract
This study provided significant evidence for the prolonged benefits of sEVs as a drug delivery system. Also, EV-mediated drug delivery systems could be considered for clinical application of retinal diseases as they maintain vitreous clarity in the light path due to their composition being similar to cells.
Topics & Concepts
MedicineBevacizumabDiabetic retinopathyIntravitreal administrationOphthalmologyRetinalVascular endothelial growth factorDrug deliveryNeovascularizationRetinaMacular degenerationPharmacologyDiabetes mellitusSurgeryAngiogenesisInternal medicineChemotherapyVEGF receptorsEndocrinologyChemistryBiologyOrganic chemistryNeuroscienceExtracellular vesicles in diseaseRetinal Diseases and TreatmentsNanoplatforms for cancer theranostics