Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition
Qi Zhuang, Shuangshuang Chen, Wei Zhang, Minhui Gu, Long Xiao, Yajun Li, Yunshang Yang, Chengcheng Feng, Hong Li, Dechun Geng, Zhirong Wang
Abstract
inhibition of the NF-κB pathway, which in turn improves OVX-induced OP.
Topics & Concepts
Ovariectomized ratOsteoclastRANKLBone resorptionOsteoporosisChemistryNF-κBPhosphorylationEndocrinologyInternal medicineBone mineralCancer researchDownregulation and upregulationIκBαResorptionPharmacologySignal transductionMedicineBiochemistryReceptorEstrogenActivator (genetics)GeneBone Metabolism and DiseasesBone health and treatmentsBone health and osteoporosis research