FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma
Ying Wang, Zhaojie Lyu, Yanru Qin, Xia Wang, Liang-Zhan Sun, Yu Zhang, Lanqi Gong, Shayi Wu, Shuo Han, Ying Tang, Yongxu Jia, Dora Lai‐Wan Kwong, Ngar‐Woon Kam, Xin‐Yuan Guan
Abstract
FOXO1 facilitated M0-to-M2 polarization and the recruitment of M2 macrophages in the TME via the transcriptional modulation of CCL20 and CSF-1. Our data deciphered the FOXO1-dependent mechanism in M2 macrophage infiltration in the TME of ESCC, which has implications for the development of novel prognostic and therapeutic targets to optimize the current treatment against ESCC.
Topics & Concepts
FOXO1Cancer researchMacrophage polarizationPI3K/AKT/mTOR pathwayCCL20Downregulation and upregulationChemokineCytokineTumor microenvironmentFlow cytometryBiologySmall interfering RNAProtein kinase BChemistryMolecular biologyChemokine receptorMacrophageSignal transductionImmunologyCell cultureCell biologyInflammationTransfectionIn vitroBiochemistryTumor cellsGeneGeneticsFOXO transcription factor regulationEpigenetics and DNA MethylationFerroptosis and cancer prognosis