Free Radical Cascade Carbochloromethylations of Activated Alkenes
Zhiwei Zhao, Yu‐Song Ran, Yu‐Jian Hou, Xin Chen, Xue‐Ling Ding, Cui Zhang, Ya‐Min Li
Abstract
-(arylsulfonyl)acrylamides have been developed by employing simple alkyl chlorides as the chloromethyl source. The transformations are characterized by wide functional group compatibility and utilizing readily available reagents, thus providing efficient methods for constructing polychloromethyl-substituted quinoline-2,4-diones and α-aryl-β-polychloromethylated amides.
Topics & Concepts
ReagentArylCascadeChemistryQuinolineCombinatorial chemistryAlkylFunctional groupCompatibility (geochemistry)Organic chemistryMaterials scienceChromatographyPolymerComposite materialCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryRadical Photochemical Reactions