Catalyst-free aerobic radical cascade reactions of <i>o</i>-vinylphenylisocyanides with thiols to access 2-thio-substituted quinolines
Jin Wang, Haitao Liu, Yaohui Liu, Wanting Hao, Yingqi Yang, Yanan Sun, Xianxiu Xu
Abstract
We herein report an efficient and green aerobic radical cascade reaction of o -vinylphenylisocyanides with thiols to access a broad range of 2-thio-substituted quinolines without the need for additional catalysts or oxidants.
Topics & Concepts
ChemistryThio-CatalysisCascadeCombinatorial chemistryMedicinal chemistryOrganic chemistryChromatographySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions