Enantioselective C−H Bond Functionalization Involving Arene Ruthenium(II) Catalysis
Hao Liang, Jun Wang
Abstract
The p-Cymene ruthenium(II) complex is one of the most widely used catalysts in C-H activation. However, enantioselective C-H activation promoted by arene ruthenium(II) complexes has not been realized until recently. The revealed strategies include intramolecular nitrene C-H insertion, the use of chiral transient directing groups, chiral carboxylic acid, relay catalysis, and chiral arene ligands. In this minireview, these advances are summarized and discussed in the hope of spurring further developments.
Topics & Concepts
Enantioselective synthesisRutheniumNitreneIntramolecular forceCatalysisChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis