New Secondary Metabolites from Marine-Derived Fungus Talaromyces minnesotensis BTBU20220184
Weiliang Wang, Jingjing Wang, Fuhang Song, Renming Jia, Long Wang, Xiuli Xu, Na Yang
Abstract
Six new compounds, talamitones A and B (1 and 2), demethyltalamitone B (3), talamiisocoumaringlycosides A and B (4 and 5), and talaminaphtholglycoside (6), together with six known compounds (7–12), were isolated from the marine-derived fungus Talaromyces minnesotensis BTBU20220184. The new structures were characterized by using HRESIMS and NMR. This is the first report of isocoumaringlycoside derivatives from a fungus of the Talaromyces genus. Compounds 5, 6, and 9 showed synergistic antibacterial activity against Staphylococcus aureus.
Topics & Concepts
FungusStaphylococcus aureusStereochemistryMarine fungiChemistryTwo-dimensional nuclear magnetic resonance spectroscopyAntibacterial activityMicrobiologyBiologyBotanyBacteriaGeneticsMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsPlant Pathogens and Fungal Diseases