18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2
Boda Chen, Dingchao Zhu, Chenglong Xie, Yifeng Shi, Libin Ni, Huawei Zhang, Sunlong Li, Jiajie Lu, Jian Xiao, Weiyi Xia, Chongan Huang, Xiangyang Wang
Abstract
. The findings demonstrate that 18β-GA reduces inflammation induced by IL-1β in chondrocytes. Therefore, 18β-GA could be a potential therapeutic agent for OA.
Topics & Concepts
Nitric oxideMatrix metalloproteinaseProstaglandin E2OsteoarthritisCartilageTumor necrosis factor alphaChemistryIn vivoInterleukinNitric oxide synthaseArthritisThrombospondinSynovitisADAMTSPharmacologyMedicineImmunologyEndocrinologyMetalloproteinasePathologyBiochemistryCytokineBiologyAnatomyBiotechnologyAlternative medicinePharmacological Effects of Natural CompoundsNatural product bioactivities and synthesisRheumatoid Arthritis Research and Therapies