R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast
Prashant Mishra, Arijita Chakraborty, Elaine Yeh, Wenyi Feng, Kerry Bloom, Munira A. Basrai
Abstract
This study from budding yeast provides mechanistic insights into how accumulation of R-loops at centromeric chromatin perturbs kinetochore integrity and contributes to chromosome instability.
Topics & Concepts
BiologyKinetochoreChromatinBudding yeastCentromereCell biologyChromosome instabilityChromosome segregationGeneticsYeastChromosomeGenome instabilitySaccharomyces cerevisiaeDNADNA damageGeneChromosomal and Genetic VariationsGenomics and Chromatin DynamicsMicrotubule and mitosis dynamics