Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles
Yupeng Ren, Ling Zeng, Yingsen Tang, Jing Liao, Meng Jiang, Xinxiu Cao, Hui Fan, Jinjin Chen
Abstract
The application of mRNA therapy is constrained by the current lipid nanoparticles' (LNPs) inability to target non-liver tissues. In this study, we demonstrate that ionizable lipids equipped with branched and biodegradable tails enhance the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells. This approach offers novel insights into how the chemical structure of LNPs influences their organ-specific targeting capabilities.
Topics & Concepts
Materials scienceSpleenNanoparticleNanotechnologyBiophysicsMedicineImmunologyBiologyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesLipid Membrane Structure and Behavior