<i>Aeromonas hydrophila</i> inhibits autophagy triggering cytosolic translocation of mtDNA which activates the pro-apoptotic caspase-1/IL-1β-nitric oxide axis in headkidney macrophages
Manmohan Kumar, Asha Shelly, Priyanka Dahiya, Atish Ray, Shibnath Mazumder
Abstract
induces ER-stress and inhibits mitophagy resulting in mitochondrial dysfunction which leads to mtROS production and translocation of mtDNA into cytosol triggering the activation of caspase-1/IL-1β-mediated NO production, culminating in HKM apoptosis.
Topics & Concepts
Cell biologyBiologyAutophagyAeromonas hydrophilaMitochondrionUnfolded protein responseMitochondrial ROSApoptosisCytosolEndoplasmic reticulumBiochemistryEnzymeGeneticsBacteriaCell death mechanisms and regulationAutophagy in Disease and TherapyPhagocytosis and Immune Regulation