Identification of a Novel Small Molecule STING Agonist Reshaping the Immunomicroenvironment of Pancreatic Ductal Adenocarcinoma
Pengyi Liu, Minmin Shi, Yang Liu, Yihao Liu, Jiayu Lin, Shuyu Zhai, Yizhi Cao, Dongjie Chen, Yongsheng Jiang, Chenghong Peng, Lei Zhang, Chunyong Ding, Lingxi Jiang, Baiyong Shen
Abstract
D166 is a novel and stable STING agonist that inhibits pancreatic tumor progression by activating the cGAS-STING pathway and remodeling the tumor immune microenvironment. Its combination with anti-PD-1 antibodies offers a promising strategy for overcoming the immunosuppressive barriers in pancreatic cancer, providing new therapeutic insights and directions.
Topics & Concepts
StingPancreatic ductal adenocarcinomaAgonistIdentification (biology)Small moleculeCancer researchInternal medicineMedicineBiologyChemistryReceptorPancreatic cancerBiochemistryCancerEngineeringAerospace engineeringBotanyinterferon and immune responsesUbiquitin and proteasome pathwaysNeuroblastoma Research and Treatments