Divergent reactivity of acrylamides and β-chloroenones under base-controlled palladium catalysis: construction of spirooxindoles and furan-containing 3,3-disubstituted oxindoles
Jingli Zhang, Weipeng Xu, Du Wang, Ye Yuan, Yongqi Bai, Minyan Wang, Guanbin Gao, Taolei Sun
Abstract
Divergent synthesis of spirooxindoles and furan-containing oxindoles via base-controlled palladium catalysis was achieved. The key intermediates, allene insertion, and Pd–carbene migratory insertion are supported by DFT calculations.
Topics & Concepts
ChemistryFuranAllenePalladiumCatalysisCarbeneReactivity (psychology)Combinatorial chemistryBase (topology)Organic chemistryMedicinal chemistryAlternative medicinePathologyMathematicsMathematical analysisMedicineCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Alkyne Reactions