Effects of SGLT2 inhibitor and dietary NaCl on glomerular hemodynamics assessed by micropuncture in diabetic rats
Scott C. Thomson, Volker Vallon
Abstract
It has been theorized that Na-glucose cotransporter (SGLT2) blockade slows progression of diabetic kidney disease by reducing physical strain on the glomerulus. This is the first direct measurement of intraglomerular pressure during SGLT2 blockade. Findings confirmed that SGLT2 blockade does reduce glomerular capillary pressure, that this is mediated through tubuloglomerular feedback, and that the tubuloglomerular feedback response to SGLT2 blockade involves preglomerular vasoconstriction and postglomerular vasorelaxation.
Topics & Concepts
Tubuloglomerular feedbackRenal functionInternal medicineEndocrinologyReabsorptionChemistryTubular fluidGlomerular hyperfiltrationHemodynamicsMedicineKidneyRenal glucose reabsorptionDiabetes mellitusDiabetic nephropathyType 2 diabetesDiabetes Treatment and ManagementChronic Kidney Disease and DiabetesPancreatic function and diabetes