Tailorable bimetallic nanozyme mitigates intervertebral disc degeneration by inhibiting oxidative stress and inflammageing
Anran Zhang, Haiyang Gao, Xiang‐Long Chen, Pengzhi Shi, Zhangrong Cheng, Yuhang Chen, Wu Wang, Wenbo Wu, Yang Cao, Yukun Zhang
Abstract
This work addresses the specific microenvironmental challenges in severe IDD by synchronously tackling multiple interacting pathological factors and provides a potential therapeutic strategy by multifunctional bimetallic nanozyme for IDD treatment.
Topics & Concepts
Oxidative stressDegeneration (medical)Intervertebral discBimetallic stripOxidative phosphorylationChemistryMedicineCell biologyBiophysicsPathologyAnatomyBiochemistryBiologyCatalysisSpine and Intervertebral Disc PathologyMedical Imaging and AnalysisMusculoskeletal pain and rehabilitation