Design, synthesis and biological evaluation of 2-aminopyrimidine-based LSD1 inhibitors
Xinran Wang, Cai Zhang, Xiangyu Zhang, Jiming Wang, Liyu Zhao, Dongmei Zhao, Maosheng Cheng
Topics & Concepts
ChemistryIn vivoIC50In vitroA549 cellPharmacologyInhibitory postsynaptic potentialApoptosisMicrosomeStructure–activity relationshipLead compoundHep G2PharmacokineticsBiochemistryStereochemistryBiologyNeuroscienceMedicineBiotechnologyEpigenetics and DNA MethylationReceptor Mechanisms and SignalingDrug Transport and Resistance Mechanisms