Late‐Stage Heteroarylation of Hetero(aryl)sulfonium Salts Activated by α‐Amino Alkyl Radicals
Eva Maria Alvarez, Teresa M. Karl, Florian Berger, Luca Torkowski, Tobias Ritter
Abstract
We report a late-stage heteroarylation of aryl sulfonium salts through activation with α-amino alkyl radicals in a mechanistically distinct approach from previously reported halogen-atom transfer (XAT). The new mode of activation of aryl sulfonium salts proceeds in the absence of light and photoredox catalysts, engaging a wide range of hetarenes. Furthermore, we demonstrate the applicability of this methodology in synthetically useful cross-coupling transformations.
Topics & Concepts
SulfoniumArylChemistryRadicalAlkylHalogenPhotoredox catalysisCatalysisAryl radicalCombinatorial chemistryPhotochemistrySalt (chemistry)Organic chemistryPhotocatalysisSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsE-Government and Public Services