Hyperuricemia induces lipid disturbances by upregulating the CXCL-13 pathway
Meng Jin, Qiulan Lv, Aihua Sui, Daxing Xu, Tong Zou, Miao Song, Xuelin Gong, Shichao Xing, Xiaofeng Wang
Abstract
The underlying molecular mechanism of hyperuricemia-induced lipid metabolism disorders is still unclear. The study aimed to investigate the mechanism of lipid disturbance in hyperuricemia mice model. To our knowledge, we proposed for the first time that CXCL-13 may be a key regulator of hyperuricemia and lipid metabolism disorders. These results may provide new insights for the clinical treatment of hyperuricemia.
Topics & Concepts
HyperuricemiaInternal medicineMedicineUric acidGout, Hyperuricemia, Uric AcidCase Reports on HematomasEosinophilic Disorders and Syndromes