A mechanism for exocyst-mediated tethering via Arf6 and PIP5K1C-driven phosphoinositide conversion
Hannes Maib, David H. Murray
Abstract
, driving exocyst recruitment and membrane tethering. These results provide a molecular mechanism of exocyst-mediated tethering and a unique functional requirement for phosphoinositide signaling on late-stage vesicles in the vicinity of the plasma membrane.
Topics & Concepts
ExocystTetheringCell biologyBiologyPhosphatidylinositolVesicleExocytosisLipid bilayer fusionVesicular Transport ProteinsMembraneEndosomeSignal transductionBiochemistryVacuolar protein sortingIntracellularCellular transport and secretionMicrotubule and mitosis dynamicsCRISPR and Genetic Engineering