Single-molecule brightness analysis for the determination of anticancer drug interactions with DNA
Ying Zhou, Krzysztof Bielec, Pakorn Pasitsuparoad, Robert Hołyst
Abstract
, which suggest a 1000-fold error in determining the effective concentration needed to form the drug-DNA complex. Until 2014, only one study by García [J. Phys. Chem. B, 2014, 118, 1288-1295] showed that the binding of anthracycline representative doxorubicin occurs in two reactions. We support this result by brightness analysis at a single molecular level for the four most common anthracyclines: doxorubicin, daunorubicin, epirubicin, and idarubicin.
Topics & Concepts
DaunorubicinDoxorubicinIdarubicinChemistryEpirubicinDNAAnticancer drugDrugMoleculePharmacologyBiochemistryOrganic chemistryBiologyChemotherapyCytarabineGeneticsCyclophosphamideAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryAdvanced Fluorescence Microscopy Techniques