Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors
Jian Shen, Xinxian Deng, Ran Sun, Mojdeh S. Tavallaie, Juntao Wang, Qingqing Cai, Celine Lam, Shuwen Lei, Lei Fu, Faqin Jiang
Topics & Concepts
AlogliptinChemistryPyrimidineIC50CytotoxicityStereochemistryIn vivoDocking (animal)Structure–activity relationshipLead compoundCombinatorial chemistryPharmacologyIn vitroBiochemistryDiabetes mellitusDipeptidyl peptidase-4Type 2 diabetesMedicineEndocrinologyBiologyBiotechnologyNursingDiabetes Treatment and ManagementPeptidase Inhibition and AnalysisNeuropeptides and Animal Physiology