Hacking the Permeability Barrier of Gram-Negative Bacteria
Ziyang Zhang
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVFirst ReactionsNEXTHacking the Permeability Barrier of Gram-Negative BacteriaChemoinformatics-derived permeation rules and structure-guided chemical synthesis led to the discovery of a potent antibiotic against Gram-negative pathogens.Ziyang ZhangZiyang ZhangDepartment of Chemistry, University of California, Berkeley, California 94720, United StatesEmail: [email protected]More by Ziyang Zhanghttps://orcid.org/0000-0003-0541-7211Cite this: ACS Cent. Sci. 2022, 8, 8, 1043–1046Publication Date (Web):August 10, 2022Publication History Published online10 August 2022Published inissue 24 August 2022https://pubs.acs.org/doi/10.1021/acscentsci.2c00750https://doi.org/10.1021/acscentsci.2c00750newsACS PublicationsCopyright © Published 2022 by American Chemical Society. This publication is licensed under CC-BY 4.0. License Summary*You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below:Creative Commons (CC): This is a Creative Commons license.Attribution (BY): Credit must be given to the creator.View full license*DisclaimerThis summary highlights only some of the key features and terms of the actual license. It is not a license and has no legal value. Carefully review the actual license before using these materials. This publication is Open Access under the license indicated. Learn MoreArticle Views3445Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Antibiotic resistance,Antimicrobial agents,Bacteria,Chemical synthesis,Inhibitors Get e-Alerts