Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Colton J. Bracken, Shion A. Lim, Paige Solomon, Nicholas J. Rettko, Duy Nguyen, Beth Shoshana Zha, Kaitlin Schaefer, James R. Byrnes, Jie Zhou, Irene Lui, Jia Liu, Katarina Pance, CryoEM grid freezing/collection team, Caleigh M. Azumaya, Julian R. Braxton, Axel F. Brilot, Meghna Gupta, Fei Li, Kyle E. Lopez, Arthur A. Melo, Gregory E. Merz, Frank R. Moss, Joana Paulino, Thomas H. Pospiech, Sergei Pourmal, Cristina Puchades, Alexandrea N. Rizo, Amber M. Smith, Ming Sun, Paul V. Thomas, Feng Wang, Zanlin Yu, CryoEM data processing team, Daniel Asarnow, Julian R. Braxton, Melody G. Campbell, Cynthia M. Chio, Un Seng Chio, Miles Sasha Dickinson, Devan Diwanji, Bryan Faust, Meghna Gupta, Nick Hoppe, Mingliang Jin, Fei Li, Junrui Li, Yanxin Liu, Gregory E. Merz, Henry C. Nguyen, Joana Paulino, Thomas H. Pospiech, Sergei Pourmal, Smriti Sangwan, Raphael Trenker, Donovan Trinidad, Eric Tse, Kaihua Zhang, Fengbo Zhou, Mammalian cell expression team, Caleigh M. Azumaya, Christian Billesboelle, Alisa Bowen, Melody G. Campbell, Devan Diwanji, Nick Hoppe, Yen-Li Li, Phuong Nguyen, Carlos Nowotny, Cristina Puchades, Mali Safari, Smriti Sangwan, Kaitlin Schaefer, Amber M. Smith, Raphael Trenker, Tsz Kin Martin Tsui, Natalie Whitis, Jianhua Zhao, Protein purification team, Daniel Asarnow, Caleigh M. Azumaya, Cynthia M. Chio, Bryan Faust, Meghna Gupta, Kate Kim, Michelle Moritz, Tristan W. Owens, Joana Paulino, Jessica K. Peters, Sergei Pourmal, Kaitlin Schaefer, Tsz Kin Martin Tsui, Crystallography team, J.T. Biel, Ishan Deshpande, Nadia Herrera, Huong T. Kratochvil, Xi Liu, Ursula Schulze‐Gahmen, I.D. Young, Bacterial expression team