Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice <i>via</i> modulation of gut microbiota and SCFA metabolism
Hong Song, Rui Guo, Xianbao Sun, Yuxing Kou, Xuan Ma, Yinan Chen, Lihua Song, Chunmei Yuan, Wu Yan
Abstract
= 0-5) without any other substituents. XOS administration significantly reduced the defecation time, increased the gastrointestinal transit rate, restored the gastrointestinal neurotransmitter imbalance, protected against oxidative stress, and reversed constipation-induced colonic inflammation. Fecal metabolite and microbiota analysis showed that XOS supplementation significantly increased short chain fatty acid (SCFA) levels and improved the gut microbial environment. These findings highlighted the potential of XOSs from corn cobs as an active ingredient for functional foods or as a therapeutic agent in constipation therapy.
Topics & Concepts
LoperamideGut floraConstipationChemistryMetabolismFecesFood scienceDiarrheaInternal medicineEndocrinologyGastroenterologyBiochemistryMedicineBiologyMicrobiologyMicrobial Metabolites in Food BiotechnologyGastrointestinal motility and disordersFood composition and properties