Lysosome-targeting chimeras enable targeted protein degradation
Bozhao Li, Yanyan Li, J. Jillian Zhang, Siren Badama, Xian Zhao, Liping Wang, Tian Wei Zhang, Xueting Wang, Xiaoqing Yi, Guo-Bin Ding, Xudong Wang, Xudong Wang, Xudong Wang, Guangjun Nie
Topics & Concepts
EndocytosisEndocytic cycleAsialoglycoprotein receptorInternalizationCell biologyReceptorEndosomeEndoplasmic-reticulum-associated protein degradationBiologyProtein degradationComputational biologyLinkerChemistryExtracellularReceptor-mediated endocytosisLigand (biochemistry)G protein-coupled receptorProtein–protein interactionIntracellularCell surface receptorScaffold proteinBiochemistryTarget proteinUbiquitinPlasma protein bindingMembrane proteinProtein targetingLysosomeF-box proteinTransport proteinProtein Degradation and InhibitorsClick Chemistry and ApplicationsRNA Interference and Gene Delivery