Tagging Peptides with a Redox Responsive Fluorescent Probe Enabled by Photoredox Difunctionalization of Phenylacetylenes with Sulfinates and Disulfides
Hong Liu, Guolin Li, Zhiyuan Peng, Shishuo Zhang, Xin Zhou, Qingchao Liu, Junfeng Wang, Yonghong Liu, Tiezheng Jia
Abstract
, arising from the reoxidation of hydroxyl group back to ketone by the elevated level of reactive oxygen species (ROS).
Topics & Concepts
ChemistryMoietyFluorescencePeptideRedoxPhotochemistryAlkylArylKetoneCysteineCombinatorial chemistryBODIPYReactive oxygen speciesPeptide synthesisStereochemistryOrganic chemistryEnzymeBiochemistryPhysicsQuantum mechanicsClick Chemistry and ApplicationsSulfur-Based Synthesis TechniquesChemical Synthesis and Analysis