Green and sensitive spectrofluorimetric determination of Remdesivir, an FDA approved SARS-CoV-2 candidate antiviral; application in pharmaceutical dosage forms and spiked human plasma
Heba Elmansi, Adel Ehab Ibrahim, Ibraam E. Mikhail, Fathalla Belal
Abstract
, respectively. The developed method is regarded as the first spectrofluorimetric one for the estimation of Remdesivir. The developed method was also utilized for the determination of the drug in its formulated IV infusion and in spiked human plasma. Statistical analysis verified that this method is accurate and reproducible. Moreover, the ecological impact of the developed procedures was evaluated on two recently reported assessment metrics, the Green Analytical Procedure Index (GAPI) and AGREE-analytical greenness metric, to emphasize the greenness of the procedure.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Human plasmaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Chromatography2019-20 coronavirus outbreakVirologyChemistryPharmacologyMedicineInfectious disease (medical specialty)PathologyOutbreakDiseaseAnalytical Methods in PharmaceuticalsAntibiotics Pharmacokinetics and EfficacyPharmacological Effects and Assays