Electrochemical Regioselective Phosphorylation of Nitrogen‐Containing Heterocycles and Related Derivatives
Yong Deng, Shiqi You, Mengyao Ruan, Ying Wang, Zuxing Chen, Guichun Yang, Meng Gao
Abstract
Abstract The site‐selective functionalization of biologically important nitrogen‐containing heterocycles and related derivatives remains a challenging and important task. We report herein on the direct regiodivergent N1/C2 phosphorylation of free indole derivatives. Cyclic voltammograms and EPR data indicate that by utilizing different electrolyte‐mediated anodic oxidation to generate different active indole species, a diverse collection of N1 and C2 phosphorylation products could be obtained in moderate to high yields under exogenous‐oxidant‐free and metal‐catalyst‐free electrochemical conditions. In addition, N−P coupling was also found to be compatible with various alkylamines. magnified image