LC-MS/MS determination of avanafil and its metabolites in rat plasma and brain: pharmacokinetic study after oral administration and transdermal film application
Ahmed K. Kammoun, Alaa Khedr, Osama A. A. Ahmed
Abstract
value of 7.05 ± 1.59 h, for oral AVA suspension and transdermal film, respectively. The average percentage of total metabolites in plasma and brain was 27.1 ± 2.2% and 7.0 ± 1.0%, respectively.
Topics & Concepts
TransdermalPharmacokineticsPharmacologyChemistryPlasma concentrationChromatographyPlasmaMedicinePhysicsQuantum mechanicsSexual function and dysfunction studiesHormonal and reproductive studiesPharmacological Effects and Toxicity Studies