Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment
Adel A. Marzouk, Ehab S. Taher, Montaser Sh. A. Shaykoon, Ping Lan, Walaa Hamada Abd‐Allah, Adel Mohamed Aboregela, Mohammed Farrag El‐Behairy
Topics & Concepts
In vivoChemistryPharmacologyCelecoxibApoptosisPyrazoleEdemaIn vitroSelectivityGene expressionBiochemistryGeneStereochemistryBiologyInternal medicineMedicineBiotechnologyCatalysisSynthesis and biological activityInflammatory mediators and NSAID effectsComputational Drug Discovery Methods