Pharmacokinetic Study of Rectal Artesunate in Children with Severe Malaria in Africa
Caterina Fanello, Richard M. Hoglund, Sue J. Lee, Daddy K. Kayembe, Pauline Ndjowo, Charlie Kabedi, Benjamin B. Badjanga, Phettree Niamyim, Joel Tärning, Charles J. Woodrow, Melba Gomes, Nick Day, Nicholas J. White, Marie A. Onyamboko
Abstract
When severe malaria is suspected in children, the WHO recommends pretreatment with a single rectal dose of artesunate before referral to an appropriate facility. This was an individually randomized, open-label, 2-arm, crossover clinical trial in 83 Congolese children with severe falciparum malaria to characterize the pharmacokinetics of rectal artesunate.
Topics & Concepts
ArtesunateDihydroartemisininMedicinePharmacokineticsRectal administrationDosingPharmacologyPlasmodium falciparumMalariaGastroenterologyInternal medicineArtemisininImmunologyMalaria Research and ControlDrug-Induced Hepatotoxicity and ProtectionMosquito-borne diseases and control