K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
J.M. Ostrem, Ulf Peters, Martin L. Sos, James A. Wells, Kevan M. Shokat
Topics & Concepts
Allosteric regulationGTP'GTPaseEffectorMutantNucleotideSmall GTPaseGTPase-activating proteinBiochemistryCell biologyChemistryBiologyG proteinSignal transductionEnzymeGeneProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerBiochemical and Molecular Research