Sigma receptors and neurological disorders
Agnieszka Piechal, Alicja Jakimiuk, Dagmara Mirowska-Guzeł
Abstract
ABSTARCT: Sigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs. Changes in sigma receptor function or expression may be involved in neurological diseases, and thus sigma receptors represent a potential target for treating central nervous system disorders. Many substances that are ligands for sigma receptors are widely used in therapies for neurological disorders. In the present review, we discuss the roles of sigma receptors, especially in the central nervous system disorders, and related therapies.
Topics & Concepts
Sigma receptorReceptorCentral nervous systemSigma-1 receptorNeuroscienceSigmaNervous systemMedicinePeripheral nervous systemPharmacologyBiologyInternal medicinePhysicsAgonistQuantum mechanicsPharmacological Receptor Mechanisms and EffectsReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research