Hypogammaglobulinemia and Infections in Patients With Multiple Sclerosis Treated With Rituximab
Marine Perriguey, Adil Maarouf, Jan-Patrick Stellmann, Audrey Rico, Clemence Boutiere, Sarah Demortiere, Pierre Durozard, Jean Pelletier, Bertrand Audoin
Abstract
BACKGROUND AND OBJECTIVES: To determine the frequency of hypogammaglobulinemia and infections in patients with multiple sclerosis (PwMS) receiving rituximab (RTX). METHODS: This prospective observational study included all consecutive PwMS receiving RTX at the university hospital of Marseille, France, between 2015 and 2020. Patient visits occurred at least every 6 months. RESULTS: = 0.01). DISCUSSION: In PwMS receiving RTX, reduced IgG level was frequent and interacted with the risk of infection.
Topics & Concepts
MedicineHypogammaglobulinemiaMultiple sclerosisRituximabImmunologyImmunopathologyInternal medicineAntibodyAutoimmune diseaseRisk factorDiseaseImmune systemImmunoglobulin GImmunodeficiency and Autoimmune DisordersMultiple Sclerosis Research StudiesInflammatory Myopathies and Dermatomyositis