MicroRNA-325-3p prevents sevoflurane-induced learning and memory impairment by inhibiting Nupr1 and C/EBPβ/IGFBP5 signaling in rats
Lili Xu, Qi Xu, Fang Xu, Wenxin Zhang, Qing Chen, Hui Wu, Xinzhong Chen
Abstract
. These results suggest that miR-325-3p blocks sevoflurane-induced learning and memory impairments by inhibiting Nupr1 and the downstream C/EBPβ/IGFBP5 signaling axis in neonatal rats. MiR-325-3p may therefore be a useful therapeutic target in sevoflurane-induced neurotoxicity.
Topics & Concepts
SevofluraneNeurotoxicityEndoplasmic reticulumApoptosisHippocampal formationmicroRNAGene knockdownMemory impairmentIn vivoChemistryMedicineCancer researchNeuroscienceCell biologyBiologyPharmacologyInternal medicineCognitionToxicityBiochemistryGeneBiotechnologyAnesthesia and Neurotoxicity ResearchIntensive Care Unit Cognitive DisordersAnesthesia and Sedative Agents