m<sup>6</sup>A methyltransferase METTL3 promotes oral squamous cell carcinoma progression through enhancement of IGF2BP2-mediated SLC7A11 mRNA stability.
Le Xu, Qingxiang Li, Yifei Wang, Lin Wang, Yuxing Guo, Rong Yang, Na Zhao, Na Ge, Yixiang Wang, Chuan Guo
Abstract
A-mediated binding of IGF2BP2, which thus promotes OSCC progression, and triptolide inhibits OSCC by suppressing METTL3-SLC7A11 axis. Triptolide has a potential to be as an effective anti-OSCC drug targeted to METTL3.
Topics & Concepts
Gene knockdownMessenger RNACancer researchFlow cytometryBiologyMolecular biologyApoptosisGeneBiochemistryRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research