Three-Component Ring-Expansion Reaction of Indoles Leading to Synthesis of Pyrrolo[2,3-<i>c</i>]quinolines
Jinjin Chen, Shuxin Jiang, Weiliang Shi, Pingyu Jiang, Xinping Liu, Huawen Huang, Guo‐Jun Deng
Abstract
Herein, we have developed an atom- and step-economic three-component cascade reaction that enables a modular platform for the synthesis of pyrrolo[2,3- c ]quinoline compounds through ring-expansion/cyclization by way of novel N1–C2 cleavage of indoles. The metal-free catalytic system exhibits a broad functional group tolerance.
Topics & Concepts
ChemistryRing (chemistry)QuinolineCatalysisCascade reactionCombinatorial chemistryCleavage (geology)StereochemistryComponent (thermodynamics)Organic chemistryEngineeringGeotechnical engineeringPhysicsFracture (geology)ThermodynamicsCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Characterization of Pyrroles