The role of ubiquitination and deubiquitination in tumor invasion and metastasis
Shuangze Han, Ruike Wang, Yangnan Zhang, Xiaoying Li, Yu Gan, Feng Gao, Pengfei Rong, Wei Wang, Wei Li
Abstract
Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.
Topics & Concepts
UbiquitinMetastasisDeubiquitinating enzymeBiologyCancer researchUbiquitin ligaseTumor progressionCell biologyCancerGeneticsGeneUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysHistone Deacetylase Inhibitors Research