Glucocorticoids promote steroid-induced osteonecrosis of the femoral head by down-regulating serum alpha-2-macroglobulin to induce oxidative stress and facilitate SIRT2-mediated BMP2 deacetylation
Shanhong Fang, Tianmin He, Mengqiang You, Huixin Zhu, Peng Chen
Topics & Concepts
SIRT2AcetylationGlucocorticoidCell biologyOxidative stressGene knockdownChemistryApoptosisBiologySirtuinCancer researchEndocrinologyBiochemistryGeneBone and Joint DiseasesBone health and treatmentsAdenosine and Purinergic Signaling